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polymerase (DNA directed), theta

On chromosome: 3q13.33
Known also as: POLH; PRO0327; DKFZp781A0112;

NCBI Gene ID: 10721
NCBI Ensembl Id: ENSG00000051341
MIM Id: (from NCBI OMIM database) 604419
Species: Homo sapiens

Gene sequence:
[Download sequence]

Proteins coded by this gene:

Authors Title Journal
Sharief FS, Vojta PJ, Ropp PA, Copeland WC Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase. Genomics July 1, 1999
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Mejean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Carcinogenesis May 1, 2009
Hussain SK, Mu LN, Cai L, Chang SC, Park SL, Oh SS, Wang Y, Goldstein BY, Ding BG, Jiang Q, Rao J, You NC, Yu SZ, Papp JC, Zhao JK, Wang H, Zhang ZF Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. Cancer Epidemiol Biomarkers Prev Aug. 1, 2009
Lemee F, Bergoglio V, Fernandez-Vidal A, Machado-Silva A, Pillaire MJ, Bieth A, Gentil C, Baker L, Martin AL, Leduc C, Lam E, Magdeleine E, Filleron T, Oumouhou N, Kaina B, Seki M, Grimal F, Lacroix-Triki M, Thompson A, Roche H, Bourdon JC, Wood RD, Hoffmann JS, Cazaux C DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability. Proc Natl Acad Sci U S A July 27, 2010

Last modification of this entry: Oct. 6, 2010.

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