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DCLRE1ADNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) |
Known also as: PSO2; SNM1; SNM1A; KIAA0086;
| NCBI Gene ID: | 9937 |
| NCBI Ensembl Id: | ENSG00000198924 |
| MIM Id: (from NCBI OMIM database) | 609682 |
| Species: | Homo sapiens |
| DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Hejna J, Philip S, Ott J, Faulkner C, Moses R | The hSNM1 protein is a DNA 5'-exonuclease. | Nucleic Acids Res Jan. 1, 2007 |
| Hazrati A, Ramis-Castelltort M, Sarkar S, Barber LJ, Schofield CJ, Hartley JA, McHugh PJ | Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. | DNA Repair (Amst) Jan. 1, 2008 |
| Hemphill AW, Bruun D, Thrun L, Akkari Y, Torimaru Y, Hejna K, Jakobs PM, Hejna J, Jones S, Olson SB, Moses RE | Mammalian SNM1 is required for genome stability. | Mol Genet Metab May 1, 2008 |
| Akhter S, Legerski RJ | SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint. | Biochem Biophys Res Commun Dec. 5, 2008 |
| Yang K, Moldovan GL, D'Andrea AD | RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger. | J Biol Chem June 18, 2010 |
Last modification of this entry: Oct. 6, 2010.
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