REPAIRtoire - a database of DNA repair pathways

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DCLRE1A

DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)

On chromosome: 10q25.1
Known also as: PSO2; SNM1; SNM1A; KIAA0086;


NCBI Gene ID: 9937
NCBI Ensembl Id: ENSG00000198924
MIM Id: (from NCBI OMIM database) 609682
Species: Homo sapiens

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Hejna J, Philip S, Ott J, Faulkner C, Moses R The hSNM1 protein is a DNA 5'-exonuclease. Nucleic Acids Res Jan. 1, 2007
Hazrati A, Ramis-Castelltort M, Sarkar S, Barber LJ, Schofield CJ, Hartley JA, McHugh PJ Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. DNA Repair (Amst) Jan. 1, 2008
Hemphill AW, Bruun D, Thrun L, Akkari Y, Torimaru Y, Hejna K, Jakobs PM, Hejna J, Jones S, Olson SB, Moses RE Mammalian SNM1 is required for genome stability. Mol Genet Metab May 1, 2008
Akhter S, Legerski RJ SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint. Biochem Biophys Res Commun Dec. 5, 2008
Yang K, Moldovan GL, D'Andrea AD RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger. J Biol Chem June 18, 2010

Last modification of this entry: Oct. 6, 2010.

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