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RAD51L1RAD51-like 1 (S. cerevisiae) |
Known also as: REC2; R51H2; hREC2; RAD51B; MGC34245;
| NCBI Gene ID: | 5890 |
| NCBI Ensembl Id: | ENSG00000182185 |
| MIM Id: (from NCBI OMIM database) | 602948 |
| Species: | Homo sapiens |
| The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Albala JS, Thelen MP, Prange C, Fan W, Christensen M, Thompson LH, Lennon GG | Identification of a novel human RAD51 homolog, RAD51B. | Genomics Dec. 15, 1997 |
| Cartwright R, Dunn AM, Simpson PJ, Tambini CE, Thacker J | Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family. | Nucleic Acids Res April 1, 1998 |
| Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J | Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. | Breast Cancer Res Treat May 23, 2010 |
| Liu Y, Shete S, Wang LE, El-Zein R, Etzel CJ, Liang FW, Armstrong G, Tsavachidis S, Gilbert M, Aldape K, Xing J, Wu X, Wei Q, Bondy ML | Gamma-Radiation Sensitivity and Polymorphisms in RAD51L1 Modulate Glioma Risk. | Carcinogenesis July 7, 2010 |
| Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF | Variation within DNA repair pathway genes and risk of multiple sclerosis. | Am J Epidemiol July 15, 2010 |
Last modification of this entry: Oct. 6, 2010.
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