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menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)

On chromosome: 14q23
Known also as: MAT1; TFB3; CAP35; RNF66;

NCBI Gene ID: 4331
NCBI Ensembl Id: ENSG00000020426
MIM Id: (from NCBI OMIM database) 602659
Species: Homo sapiens

Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'menage a trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM]

Gene sequence:
[Download sequence]

Proteins coded by this gene:

Authors Title Journal
Kershnar E, Wu SY, Chiang CM Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. J Biol Chem Dec. 18, 1998
Busso D, Keriel A, Sandrock B, Poterszman A, Gileadi O, Egly JM Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities. J Biol Chem July 28, 2000
Sandrock B, Egly JM A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH. J Biol Chem Sept. 21, 2001

Last modification of this entry: Oct. 6, 2010.

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