REPAIRtoire - a database of DNA repair pathways

Welcome! Click here to login or here to register.
DNA damage
Draw a picture

Bujnicki Lab Homepage


X-ray repair complementing defective repair in Chinese hamster cells 6

On chromosome: 22q13.2-q13.31
Known also as: ML8; KU70; TLAA; CTC75; CTCBF; G22P1;

NCBI Gene ID: 2547
NCBI Ensembl Id: ENSG00000196419
MIM Id: (from NCBI OMIM database) 152690
Species: Homo sapiens

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq]

Gene sequence:
[Download sequence]

Proteins coded by this gene:

Authors Title Journal
Wedrychowski A, Henzel W, Huston L, Paslidis N, Ellerson D, McRae M, Seong D, Howard OM, Deisseroth A Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells. J Biol Chem March 5, 1992
Tuteja N, Tuteja R, Ochem A, Taneja P, Huang NW, Simoncsits A, Susic S, Rahman K, Marusic L, Chen J, et al. Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. EMBO J Oct. 17, 1994
Bianchi A, de Lange T Ku binds telomeric DNA in vitro. J Biol Chem July 23, 1999
Cooper MP, Machwe A, Orren DK, Brosh RM, Ramsden D, Bohr VA Ku complex interacts with and stimulates the Werner protein. Genes Dev April 15, 2000
Kim E, Li K, Lieu C, Tong S, Kawai S, Fukutomi T, Zhou Y, Wands J, Li J Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis. J Hepatol Nov. 1, 2008

Last modification of this entry: Oct. 6, 2010.

Add your own comment!

There is no comment yet.
Welcome stranger! Click here to login or here to register.
Valid HTML 4.01! This site is Emacs powered. Made with Django.