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POLR2Epolymerase (RNA) II (DNA directed) polypeptide E, 25kDa |
Known also as: RPB5; XAP4; RPABC1; hRPB25; hsRPB5;
| NCBI Gene ID: | 5434 |
| NCBI Ensembl Id: | ENSG00000099817 |
| MIM Id: (from NCBI OMIM database) | 180664 |
| Species: | Homo sapiens |
| This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Orphanides G, Lagrange T, Reinberg D | The general transcription factors of RNA polymerase II. | Genes Dev Nov. 1, 1996 |
| Holstege FC, Fiedler U, Timmers HT | Three transitions in the RNA polymerase II transcription complex during initiation. | EMBO J Dec. 15, 1997 |
| Kershnar E, Wu SY, Chiang CM | Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. | J Biol Chem Dec. 18, 1998 |
| Zhou Z, Licklider LJ, Gygi SP, Reed R | Comprehensive proteomic analysis of the human spliceosome. | Nature Sept. 12, 2002 |
Last modification of this entry: Oct. 6, 2010.
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