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polymerase (RNA) II (DNA directed) polypeptide E, 25kDa

On chromosome: 19p13.3
Known also as: RPB5; XAP4; RPABC1; hRPB25; hsRPB5;

NCBI Gene ID: 5434
NCBI Ensembl Id: ENSG00000099817
MIM Id: (from NCBI OMIM database) 180664
Species: Homo sapiens

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. [provided by RefSeq]

Gene sequence:
[Download sequence]

Proteins coded by this gene:

Authors Title Journal
Orphanides G, Lagrange T, Reinberg D The general transcription factors of RNA polymerase II. Genes Dev Nov. 1, 1996
Holstege FC, Fiedler U, Timmers HT Three transitions in the RNA polymerase II transcription complex during initiation. EMBO J Dec. 15, 1997
Kershnar E, Wu SY, Chiang CM Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. J Biol Chem Dec. 18, 1998
Zhou Z, Licklider LJ, Gygi SP, Reed R Comprehensive proteomic analysis of the human spliceosome. Nature Sept. 12, 2002

Last modification of this entry: Oct. 6, 2010.

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