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MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae) |
Known also as: ATLD; HNGS1; MRE11; MRE11B;
| NCBI Gene ID: | 4361 |
| NCBI Ensembl Id: | ENSG00000020922 |
| MIM Id: (from NCBI OMIM database) | 600814 |
| Species: | Homo sapiens |
| This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
Diseases related to this gene:
References:
| Authors | Title | Journal |
| Paull TT, Gellert M | The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. | Mol Cell June 1, 1998 |
| Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K | ATM-dependent phosphorylation of nibrin in response to radiation exposure. | Nat Genet May 1, 2000 |
| Lee JH, Paull TT | ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. | Science April 22, 2005 |
Last modification of this entry: Oct. 6, 2010.
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