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On chromosome: 13q34
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CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM]
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Gene sequence:
Proteins coded by this gene:
References:
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Authors
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Title
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Journal
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Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM
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cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
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Cell
June 14, 1996
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Liu J, Furukawa M, Matsumoto T, Xiong Y
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NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.
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Mol Cell
Dec. 1, 2002
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Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF
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A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
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Genes Dev
Nov. 15, 2008
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Last modification of this entry: Oct. 6, 2010.
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