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RFC5replication factor C (activator 1) 5, 36.5kDa |
Known also as: RFC36; MGC1155;
| NCBI Gene ID: | 5985 |
| NCBI Ensembl Id: | ENSG00000111445 |
| MIM Id: (from NCBI OMIM database) | 600407 |
| Species: | Homo sapiens |
| The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Mossi R, Jonsson ZO, Allen BL, Hardin SH, Hubscher U | Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. | J Biol Chem Feb. 17, 1997 |
| Ellison V, Stillman B | Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. | J Biol Chem March 6, 1998 |
| Zou L, Elledge SJ | Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. | Science June 6, 2003 |
Last modification of this entry: Oct. 6, 2010.
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