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RFC4replication factor C (activator 1) 4, 37kDa |
Known also as: A1; RFC37; MGC27291;
| NCBI Gene ID: | 5984 |
| NCBI Ensembl Id: | ENSG00000163918 |
| MIM Id: (from NCBI OMIM database) | 102577 |
| Species: | Homo sapiens |
| The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K, et al. | Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. | Genomics Feb. 1, 1995 |
| Zou L, Elledge SJ | Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. | Science June 6, 2003 |
| Gupte RS, Weng Y, Liu L, Lee MY | The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival. | Cell Cycle Jan. 1, 2005 |
| Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC Jr | Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. | J Biol Chem Feb. 21, 2005 |
Last modification of this entry: Oct. 6, 2010.
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