REPAIRtoire - a database of DNA repair pathways

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Bujnicki Lab Homepage

RFC4

replication factor C (activator 1) 4, 37kDa

On chromosome: 3q27
Known also as: A1; RFC37; MGC27291;


NCBI Gene ID: 5984
NCBI Ensembl Id: ENSG00000163918
MIM Id: (from NCBI OMIM database) 102577
Species: Homo sapiens

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq]


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K, et al. Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. Genomics Feb. 1, 1995
Zou L, Elledge SJ Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science June 6, 2003
Gupte RS, Weng Y, Liu L, Lee MY The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival. Cell Cycle Jan. 1, 2005
Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC Jr Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. J Biol Chem Feb. 21, 2005

Last modification of this entry: Oct. 6, 2010.

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