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RFC3replication factor C (activator 1) 3, 38kDa |
Known also as: RFC38; MGC5276;
| NCBI Gene ID: | 5983 |
| NCBI Ensembl Id: | ENSG00000133119 |
| MIM Id: (from NCBI OMIM database) | 600405 |
| Species: | Homo sapiens |
| The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Ellison V, Stillman B | Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. | J Biol Chem March 6, 1998 |
| Zou L, Elledge SJ | Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. | Science June 6, 2003 |
Last modification of this entry: Oct. 6, 2010.
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