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POLR2Lpolymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa |
Known also as: RBP10; RPB10; RPABC5; RPB7.6; hRPB7.6; hsRPB10b; RPB10beta;
| NCBI Gene ID: | 5441 |
| NCBI Ensembl Id: | ENSG00000177700 |
| MIM Id: (from NCBI OMIM database) | 601189 |
| Species: | Homo sapiens |
| This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M | The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase. | Genomics Jan. 15, 1996 |
| Holstege FC, Fiedler U, Timmers HT | Three transitions in the RNA polymerase II transcription complex during initiation. | EMBO J Dec. 15, 1997 |
| Kershnar E, Wu SY, Chiang CM | Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. | J Biol Chem Dec. 18, 1998 |
| Zhou Z, Licklider LJ, Gygi SP, Reed R | Comprehensive proteomic analysis of the human spliceosome. | Nature Sept. 12, 2002 |
Last modification of this entry: Oct. 6, 2010.
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