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polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa

On chromosome: 11p15
Known also as: RBP10; RPB10; RPABC5; RPB7.6; hRPB7.6; hsRPB10b; RPB10beta;

NCBI Gene ID: 5441
NCBI Ensembl Id: ENSG00000177700
MIM Id: (from NCBI OMIM database) 601189
Species: Homo sapiens

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq]

Gene sequence:
[Download sequence]

Proteins coded by this gene:

Authors Title Journal
Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase. Genomics Jan. 15, 1996
Holstege FC, Fiedler U, Timmers HT Three transitions in the RNA polymerase II transcription complex during initiation. EMBO J Dec. 15, 1997
Kershnar E, Wu SY, Chiang CM Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. J Biol Chem Dec. 18, 1998
Zhou Z, Licklider LJ, Gygi SP, Reed R Comprehensive proteomic analysis of the human spliceosome. Nature Sept. 12, 2002

Last modification of this entry: Oct. 6, 2010.

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