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polymerase (RNA) II (DNA directed) polypeptide F

On chromosome: 22q13.1
Known also as: RPB6; POLRF; RPABC2; RPB14.4; HRBP14.4;

NCBI Gene ID: 5435
NCBI Ensembl Id: ENSG00000100142
MIM Id: (from NCBI OMIM database) 604414
Species: Homo sapiens

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. [provided by RefSeq]

Gene sequence:
[Download sequence]

Proteins coded by this gene:

Authors Title Journal
Orphanides G, Lagrange T, Reinberg D The general transcription factors of RNA polymerase II. Genes Dev Nov. 1, 1996
Holstege FC, Fiedler U, Timmers HT Three transitions in the RNA polymerase II transcription complex during initiation. EMBO J Dec. 15, 1997
Kershnar E, Wu SY, Chiang CM Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. J Biol Chem Dec. 18, 1998
Zhou Z, Licklider LJ, Gygi SP, Reed R Comprehensive proteomic analysis of the human spliceosome. Nature Sept. 12, 2002

Last modification of this entry: Oct. 6, 2010.

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