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TDG
thymine-DNA glycosylase
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On chromosome: 12q24.1
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The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]
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Gene sequence:
Proteins coded by this gene:
References:
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Authors
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Title
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Journal
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Neddermann P, Gallinari P, Lettieri T, Schmid D, Truong O, Hsuan JJ, Wiebauer K, Jiricny J
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Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase.
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J Biol Chem
May 31, 1996
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Barrett TE, Savva R, Panayotou G, Barlow T, Brown T, Jiricny J, Pearl LH
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Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions.
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Cell
Feb. 9, 1998
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Lindahl T, Wood RD
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Quality control by DNA repair.
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Science
Dec. 3, 1999
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Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM
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Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.
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Genomics
Feb. 1, 2004
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Last modification of this entry: Oct. 6, 2010.
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