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alkA
Unnamed Gene ID: 947371
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Known also as: aidA; ECK2062; JW2053;
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The alk gene product is known as 3-methyladenine-DNA glycosylase II and is induced by exposure to alkylating agents as part of the cell's adaptive response to damage caused by alkylation. [More information is available at EcoCyc: EG11222].
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Gene sequence:
Proteins coded by this gene:
References:
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Authors
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Title
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Journal
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Teo I, Sedgwick B, Kilpatrick MW, McCarthy TV, Lindahl T
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The intracellular signal for induction of resistance to alkylating agents in E. coli.
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Cell
April 25, 1986
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Fram RJ, Marinus MG, Volkert MR
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Gene expression in E. coli after treatment with streptozotocin.
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Mutat Res
March 1, 1988
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Volkert MR, Gately FH, Hajec LI
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Expression of DNA damage-inducible genes of Escherichia coli upon treatment with methylating, ethylating and propylating agents.
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Mutat Res
March 1, 1989
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Shevell DE, Walker GC
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A region of the Ada DNA-repair protein required for the activation of ada transcription is not necessary for activation of alkA.
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Proc Natl Acad Sci U S A
Oct. 15, 1991
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Matijasevic Z, Sekiguchi M, Ludlum DB
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Release of N2,3-ethenoguanine from chloroacetaldehyde-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II.
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Proc Natl Acad Sci U S A
Oct. 1, 1992
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Last modification of this entry: Oct. 6, 2010.
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