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FANCGFanconi anemia, complementation group G |
Known also as: FAG; XRCC9;
| NCBI Gene ID: | 2189 |
| NCBI Ensembl Id: | ENSG00000221829 |
| MIM Id: (from NCBI OMIM database) | 602956 |
| Species: | Homo sapiens |
| The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
Diseases related to this gene:
References:
| Authors | Title | Journal |
| Liu N, Lamerdin JE, Tucker JD, Zhou ZQ, Walter CA, Albala JS, Busch DB, Thompson LH | The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells. | Proc Natl Acad Sci U S A Aug. 19, 1997 |
| de Winter JP, Waisfisz Q, Rooimans MA, van Berkel CG, Bosnoyan-Collins L, Alon N, Carreau M, Bender O, Demuth I, Schindler D, Pronk JC, Arwert F, Hoehn H, Digweed M, Buchwald M, Joenje H | The Fanconi anaemia group G gene FANCG is identical with XRCC9. | Nat Genet Nov. 1, 1998 |
| Mukhopadhyay SS, Leung KS, Hicks MJ, Hastings PJ, Youssoufian H, Plon SE | Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia. | J Cell Biol Oct. 23, 2006 |
| Xin X, Rual JF, Hirozane-Kishikawa T, Hill DE, Vidal M, Boone C, Thierry-Mieg N | Shifted Transversal Design smart-pooling for high coverage interactome mapping. | Genome Res July 1, 2009 |
Last modification of this entry: Oct. 6, 2010.
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