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MSH3mutS homolog 3 (E. coli) |
Known also as: DUP; MRP1; MGC163306; MGC163308;
| NCBI Gene ID: | 4437 |
| NCBI Ensembl Id: | ENSG00000113318 |
| MIM Id: (from NCBI OMIM database) | 600887 |
| Species: | Homo sapiens |
| The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
Diseases related to this gene:
References:
| Authors | Title | Journal |
| Acharya S, Wilson T, Gradia S, Kane MF, Guerrette S, Marsischky GT, Kolodner R, Fishel R | hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. | Proc Natl Acad Sci U S A Nov. 26, 1996 |
| Schmutte C, Sadoff MM, Shim KS, Acharya S, Fishel R | The interaction of DNA mismatch repair proteins with human exonuclease I. | J Biol Chem Aug. 31, 2001 |
| Plotz G, Raedle J, Brieger A, Trojan J, Zeuzem S | hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA. | Nucleic Acids Res Jan. 1, 2002 |
Last modification of this entry: Oct. 6, 2010.
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