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TOPBP1topoisomerase (DNA) II binding protein 1 |
Known also as: TOP2BP1;
| NCBI Gene ID: | 11073 |
| NCBI Ensembl Id: | ENSG00000163781 |
| MIM Id: (from NCBI OMIM database) | 607760 |
| Species: | Homo sapiens |
| This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Yamane K, Kawabata M, Tsuruo T | A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator. | Eur J Biochem Dec. 15, 1997 |
| Xu ZX, Timanova-Atanasova A, Zhao RX, Chang KS | PML colocalizes with and stabilizes the DNA damage response protein TopBP1. | Mol Cell Biol June 1, 2003 |
Last modification of this entry: Oct. 13, 2010.
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