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GASTRIC CANCER
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In a review article on the genetic predisposition to gastric cancer it was concluded that several genes may be associated with an increased risk of gastric cancer. Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; familial adenomatous polyposis (FAP; 175100), Peutz-Jeghers syndrome (PJS; 175200), Cowden disease (CD; 158350), and the Li-Fraumeni syndrome.
Somatic mutations in various genes have also been identified in gastric cancer tumor tissue. These genes include APC (611731), IRF1 (147575), KLF6 (602053), MUTYH (604933), KRAS (190070), CASP10 (601762), PIK3CA (171834), ERBB2 (164870), and FGFR2 (176943). |
DNA repair proteins related with GASTRIC CANCER (137215 ) disease:
Last modification of this entry: Oct. 11, 2010.
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