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NHEJ: DNA-PKcs autophosphorylation
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Very important step of NHEJ, as the presence of unphosphorylated DNA-PKcs molecule effectively blocks binding of processing enzymes and ligases, and inhibits ligation of DNA ends. |
DNA/Ku70/80 complex with DNA-PKcs in Homo sapiens | |
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DNA-PKcs autophosphorylated in Homo sapiens |
Authors | Title | Journal |
Weterings E, Chen DJ | The endless tale of non-homologous end-joining | Cell Res. Jan. 1, 2008 |