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"Coupling of human circadian and cell cycles by the timeless protein."

Unsal-Kacmaz K, Mullen TE, Kaufmann WK, Sancar A



Published April 1, 2005 in Mol Cell Biol volume 25 .

Pubmed ID: 15798197

Abstract:
The Timeless protein is essential for circadian rhythm in Drosophila. The Timeless orthologue in mice is essential for viability and appears to be required for the maintenance of a robust circadian rhythm as well. We have found that the human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.


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Last modification of this entry: Oct. 6, 2010

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