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"Negative regulation of filamentous growth and flocculation by Lkh1, a fission yeast LAMMER kinase homolog." |
Kim KH, Cho YM, Kang WH, Kim JH, Byun KH, Park YD, Bae KS, Park HM |
Published Dec. 21, 2001 in Biochem Biophys Res Commun volume 289 .
Pubmed ID: 11741326
Abstract:
| We have isolated a full-length cDNA clone that encodes for a Schizosaccharomyces pombe homolog of the dual-specificity protein kinase of the LAMMER family, lkh1 (lammer kinase homolog). The proposed Lkh1 protein contains 575 amino acids. The lkh1(+) null mutant is viable, but exhibits flocculation upon reaching stationary phase in liquid media and filamentous adhesion growth on solid media. Analysis of the flocculation activity of the lkh1(+) null mutant indicates that asexual aggregation of S. pombe cells into floccules is divalent cation-dependent and galactose-specific. We also demonstrate that the Saccharomyces cerevisiae LAMMER kinase homolog, Kns1, can substitute for the Lkh1 function in S. pombe. |
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Last modification of this entry: Oct. 6, 2010
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