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"Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct." |
Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH |
Published Aug. 1, 1998 in Nat Struct Biol volume 5 .
Pubmed ID: 9699633
Abstract:
| Base-excision of a self-complementary oligonucleotide with central G:T mismatches by the G:T/U-specific mismatch DNA glycosylase (MUG), generates an unusual DNA structure which is remarkably similar in conformation to an interstrand DNA adduct of the anti-tumor drug cis-diamminedichloroplatinum. The abasic sugars generated by excision of the mismatched thymines are extruded from the double-helix, and the 'widowed' deoxyguanosines rotate so that their N7 and O6 groups protrude into the minor groove of the duplex and restack in an interleaved intercalative geometry, generating a kink in the helix axis. |
This publication refers to following REPAIRtoire entries:
| Genes | |
| Proteins |
Last modification of this entry: Oct. 6, 2010
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