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"Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases." |
Poltoratsky VP, Shi X, York JD, Lieber MR, Carter TH |
Published Nov. 15, 1995 in J Immunol volume 155 .
Pubmed ID: 7594449
Abstract:
| DNA-activated protein kinase (DNA-PK) is a serine/threonine protein kinase that interacts with a DNA end-binding heterodimeric protein, Ku, and is activated by double-stranded DNA. Genomic clones that contain the DNA-PK gene complement the murine scid defect, indicating that DNA-PK affects double-strand break repair and V(D)J recombination. Here we describe the cDNA sequence of the region that corresponds to about 100 kDa of C-terminal sequence of this large (> p350 kDa) protein. This region contains a kinase domain that has strong homology to phosphatidylinositol kinases. |
This publication refers to following REPAIRtoire entries:
| Proteins |
Last modification of this entry: Oct. 6, 2010
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