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"[Human hR24L gene is involved in DNA excision repair and recombination repair]" |
Han Y, Zhu Y |
Published Dec. 1, 1999 in Zhonghua Yi Xue Za Zhi volume 79 .
Pubmed ID: 11715513
Abstract:
| OBJECTIVE: To study the correction phenotype of temperature sensitive mutant rad24LR of S. cerevisiae and to clone wild human functional homologue. METHODS: The temperature sensitive mutant rad24LR was studied by complementation test. Transformation of rad24LR was performed with human cDNA expression library to screen for reversion phenotype. RESULTS: RAD24L can complement the radiation sensitive phenotype of the mutation. Its homologue of human cDNA was cloned by screening transformed rad24LR with human expression library for reversion phenotype. CONCLUSION: Human DNA repair gene hR24L was successfully cloned in this study. The product hR24L is involved in both DNA excision repair and recombination repair. |
This publication refers to following REPAIRtoire entries:
| Proteins |
Last modification of this entry: Oct. 6, 2010
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