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"Replication factor A is required in vivo for DNA replication, repair, and recombination." |
Longhese MP, Plevani P, Lucchini G |
Published Dec. 1, 1994 in Mol Cell Biol volume 14 .
Pubmed ID: 7969128
Abstract:
| Replication factor A (RF-A) is a heterotrimeric single-stranded-DNA-binding protein which is conserved in all eukaryotes. Since the availability of conditional mutants is an essential step to define functions and interactions of RF-A in vivo, we have produced and characterized mutations in the RFA1 gene, encoding the p70 subunit of the complex in Saccharomyces cerevisiae. This analysis provides the first in vivo evidence that RF-A function is critical not only for DNA replication but also for efficient DNA repair and recombination. Moreover, genetic evidence indicate that p70 interacts both with the DNA polymerase alpha-primase complex and with DNA polymerase delta. |
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Last modification of this entry: Oct. 6, 2010
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