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"A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice." |
Herron BJ, Liddell RA, Parker A, Grant S, Kinne J, Fisher JK, Siracusa LD |
Published Nov. 1, 2005 in Nat Genet volume 37 .
Pubmed ID: 16200063
Abstract:
| Stratifin (Sfn, also called 14-3-3sigma) is highly expressed in differentiating epidermis and mediates cell cycle arrest. Sfn is repressed in cancer, but its function during development is uncharacterized. We identified an insertion mutation in the gene Sfn in repeated epilation (Er) mutant mice by positional cloning. Er/+ mice expressed a truncated Sfn protein, which probably contributes to the defects in Er/Er and Er/+ epidermis and to cancer development in Er/+ mice. |
This publication refers to following REPAIRtoire entries:
| Genes |
Last modification of this entry: Oct. 6, 2010
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