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"Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens." |
McKenzie GJ, Rosenberg SM |
Published Oct. 1, 2001 in Curr Opin Microbiol volume 4 .
Pubmed ID: 11587937
Abstract:
| "Adaptive" or "stationary-phase" mutation is a collection of stress responses promoting mutations, some of which are advantageous. In 2000 and 2001, in Escherichia coli, adaptive gene amplification was documented, and a parallel adaptive point-mutation mechanism was linked to the error-prone DNA polymerase, DinB (pol IV). We suggest that DinB homologues may contribute to adaptive strategies of pathogens, including antigenic variation. |
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Last modification of this entry: Oct. 7, 2010
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