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"Structure of ribonucleotide reductase protein R1." |
Uhlin U, Eklund H |
Published Aug. 18, 1994 in Nature volume 370 .
Pubmed ID: 8052308
Abstract:
| Ribonucleotide reductase is the only enzyme that catalyses de novo formation of deoxyribonucleotides and is thus a key enzyme in DNA synthesis. The radical-based reaction involves five cysteins. Two redox-active cysteines are located at adjacent antiparallel strands in a new type of ten-stranded alpha/beta-barrel, and two others at the carboxyl end in a flexible arm. The fifth cysteine, in a loop in the centre of the barrel, is positioned to initiate the radical reaction. |
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Last modification of this entry: Oct. 11, 2010
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