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"Inhibition of FtsZ polymerization by SulA, an inhibitor of septation in Escherichia coli."

Mukherjee A, Cao C, Lutkenhaus J



Published March 17, 1998 in Proc Natl Acad Sci U S A volume 95 .

Pubmed ID: 9501185

Abstract:
The bacterial cell division protein FtsZ assembles into the cytokinetic Z ring that directs cytokinesis in prokaryotes. In Escherichia coli the formation of the Z ring is prevented by induction of the cell division inhibitor SulA (SfiA), a component of the SOS response. Here we show that a MalE-SulA fusion that retains this inhibitory function in vivo inhibits the GTPase activity and polymerization of FtsZ in vitro. MalE-SulA10, which does not block Z ring formation in vivo, is unable to inhibit the GTPase activity and polymerization in vitro. Furthermore, FtsZ114, which is refractory to SulA in vivo, is not inhibited by MalE-SulA. These results indicate that SulA blocks Z ring formation by blocking FtsZ polymerization.


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Last modification of this entry: Oct. 11, 2010

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