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"The multifaceted mismatch-repair system" |
Jiricny J. |
Published May 7, 2006 in Nat Rev Mol Cell Biol. .
Pubmed ID: 16612326
Abstract:
| By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about a mutator phenotype, which causes a predisposition to cancer. But MMR status also affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes such as class-switch recombination, somatic hypermutation and triplet-repeat expansion. This article reviews our current understanding of this multifaceted DNA-repair system in human cells. |
This publication refers to following REPAIRtoire entries:
| Pathways |
Last modification of this entry: Oct. 14, 2008
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