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"Role of DNA bubble rewinding in enzymatic transcription termination." |
Park JS, Roberts JW. |
Published March 28, 2006 in Proc Natl Acad Sci U S A. volume 103 .
Pubmed ID: 16551743
Abstract:
| By using DNA heteroduplexes that inhibit rewinding of the upstream part of the transcription bubble, we show that transcript release in termination by the enzymes Mfd and Rho is facilitated by reannealing of DNA in the upstream region of the transcription bubble, as is also true for termination by intrinsic terminators. We also show that, like Mfd, the Rho termination factor promotes forward translocation of RNA polymerase. These results support termination models in which external forces imposed on nucleic acids induce concerted rewinding of DNA and unwinding of the DNA/RNA hybrid, possibly accompanied by forward translocation of RNA polymerase, leading to transcription complex dissociation. |
This publication refers to following REPAIRtoire entries:
| Pathways |
Last modification of this entry: Dec. 10, 2008
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