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Protein FULL name:
LexA (Escherichia coli strain K-12 substr. MG1655) is product of expression of lexA gene.
LexA is involved in:
DDS in Escherichia coli strain K-12 substr. MG1655
FUNCTION: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity).
CATALYTIC ACTIVITY: Hydrolysis of Ala-|-Gly bond in repressor lexA.
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the peptidase S24 family.
Links to other databases:
LexA (Escherichia coli strain K-12 substr. MG1655) belongs to following protein families:
Last modification of this entry: Oct. 13, 2010.
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