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MutL |
Protein FULL name:
MutL Protein [Escherichia coli].
MutL (Escherichia coli strain K-12 substr. MG1655) is product of expression of mutL gene.
MutL is involved in:
MMR in Escherichia coli strain K-12 substr. MG1655
- MutS interacts with MutL in Escherichia coli strain K-12 substr. MG1655
- MutS-MutL interacts with MutH in Escherichia coli strain K-12 substr. MG1655
Keywords:
FUNCTION: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of mutL is stimulated by DNA.
INTERACTION: P28630:holA; NbExp=2; IntAct=EBI-554913, EBI-549153; P28631:holB; NbExp=2; IntAct=EBI-554913, EBI-549161; P06722:mutH; NbExp=2; IntAct=EBI-554913, EBI-545170; P0A6N1:tufA; NbExp=1; IntAct=EBI-554913, EBI-301077; P03018:uvrD; NbExp=4; IntAct=EBI-554913, EBI-559573;
SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
| NCBI GenPept GI number(s): |
42067 |
| Species: | Escherichia coli |
Links to other databases:
| Database | ID | Link |
| Uniprot | P23367 |
P23367 |
| PFAM: | - |
P23367 (Link - using uniprot id) |
| InterPro: |
IPR002099 IPR003594 IPR013507 |
IPR002099 IPR003594 IPR013507 |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | 1B62 1B63 1BKN 1X9Z |
1B62 1B63 1BKN 1X9Z |
Protein sequence:
|
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGG AKLIRIRDNGCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALA SISSVSRLTLTSRTAEQQEAWQAYAEGRDMNVTVKPAAHPVGTTLEVLDL FYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYR AVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVADPNHTTPAL AEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRS IPENRVAAGRNHFAEPAAREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQ QGEVYRQLLQTPAPMQKLKAPEPQEPALAANSQSFGRVLTIVHSDCALLE RDGNISLLSLPVAERWLRQAQLTPGEAPVCAQPLLIPLRLKVSAEEKSAL EKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQS VFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLL QSVDLHPAIKALKDE |
MutL (Escherichia coli strain K-12 substr. MG1655) is able to recognize following damages:
- base deletion frameshift
- base insertion frameshift
- AG mismatch
- AA mismatch
- CA mismatch
- CC mismatch
- CT mismatch
- GA mismatch
- GG mismatch
- GT mismatch
- TC mismatch
- TG mismatch
- TT mismatch
- base mismatch
- small deletion loop
- large deletion loop
- large insertion loop
- small insertion loop
Solved crystal structures:
References:
Last modification of this entry: Oct. 13, 2010.
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