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Protein FULL name:
CPD photolyase, DNA photolyase
Phr1p (Saccharomyces cerevisiae) is product of expression of PHR1 gene.
FUNCTION: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
CATALYTIC ACTIVITY: Cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).
COFACTOR: Binds 1 FAD per subunit.
COFACTOR: Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit.
BIOPHYSICOCHEMICAL PROPERTIES: Absorption: Abs(max)=377 nm; Note=Has a fluorescence excitation maximum at 390 nm and an emission maximum at 475 nm;
SUBUNIT: Monomer (By similarity).
INTERACTION: P15179:MSD1; NbExp=1; IntAct=EBI-13385, EBI-18659; P33203:PRP40; NbExp=1; IntAct=EBI-13385, EBI-701;
SUBCELLULAR LOCATION: Nucleus. Mitochondrion.
MISCELLANEOUS: There are only 150-300 molecules of photolyase per yeast cell.
MISCELLANEOUS: Present with 688 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the DNA photolyase class-1 family.
SIMILARITY: Contains 1 DNA photolyase domain.
Links to other databases:
Phr1p (Saccharomyces cerevisiae) is able to recognize following damages:
Last modification of this entry: Nov. 14, 2020.
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