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TOP II |
Protein FULL name:
topoisomerase II [Arabidopsis thaliana].
TOP II (Arabidopsis thaliana) is product of expression of TOPII gene.
FUNCTION: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining of double-stranded DNA.
SUBUNIT: Homodimer.
MISCELLANEOUS: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
SIMILARITY: Belongs to the type II topoisomerase family.
| NCBI GenPept GI number(s): |
474890 |
| Species: | Arabidopsis thaliana |
Links to other databases:
| Database | ID | Link |
| Uniprot | P30182 |
P30182 |
| PFAM: | - |
P30182 (Link - using uniprot id) |
| InterPro: | - |
P30182 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MATKLPLQNSNAANVAKAPAKSRAAAGGKTIEEMYQKKSQLEHILLRPDT YIGSIEKHTQTLWVYEKDEMVQRPVTYVPGLYKIFDEILVNAADNKQRDA KMDSVQVVIDVEQNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSN YDDNVKKTTGGRNGYGAKLTNIFSTEFIIETADGKRLKKYKQVFENNMGK KSEPVITKCNKSENWTKVTFKPDLKKFNMTELEDDVVALMSKRVFDIAGC LGKSVKVELNGKQIPVKSFTDYVDLYLSAANKSRTEDPLPRLTEKVNDRW EVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTSQITNHIVAAVNKKNKN ANVKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDF LKKVGKSGVVENLLSWADFKQNKDLKKSDGAKTGRVLVEKLDDAAEAGGK NSRLCTLILTEGDSAKSLALAGRSVLGNNYCGVFPLRGKLLNVREASTTQ ITNNKEIENLKKILGLKQNMKYENVNSLRYGQMMIMTDQDHDGSHIKGLL INFIHSFWPSLLQVPSFLVEFITPIVKATRKGTKKVLSFYSMPEYEEWKE SLKGNATGWDIKYYKGLGTSTAEEGKEYFSNLGLHKKDFVWEDEQDGEAI ELAFSKKKIEARKNWLSSYVPGNHLDQRQPKVTYSDFVNKELILFSMADL QRSIPSMVDGLKPGQRKILFVAFKKIARKEMKVAQLVGYVSLLSAYHHGE QSLASAIIGMAQDYVGSNNINLLLPNGQFGTRTSGGKDSASARYIFTKLS PVTRILFPKDDDLLLDYLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTGWS TFIPNYNPREIVANVRRLLNGESMVPMDPWYRGFKGTIEKTASKEGGCTY TITGLYEEVDETTIRITELPIRRWNDDYKNFLQSLKTDNGAPFFQDVKAY NDEKSVDFDLILSEENMLAARQEGFLKKFKLTTTIATSNMHLFDKKGVIK KYVTPEQILEEFFDLRFEYYEKRKETVVKNMEIELLKLENKARFILAVLS GEIIVNKRKKADIVEDLRQKGFTPFPRKAESVEAAIAGAVDDDAAEEPEE ILVDPESSSSYIPGSEYDYLLAMAIASLTIEKVEELLADRDKMIIAVADM KKTTPKSLWLSDLESLDKELEKLDLKDAQVQQAIEAAQKKIRAKSGAAVK VKRQAPKKPAPKKTTKKASESETTEASYSAMDTDNNVAEVVKPKARQGAK KKASESETTEASHSAMDTDNNVAEVVKPKGRQGAKKKAPAAAKEVEEDEM LDLAQRLAQYNFGSAPADSSKTAETSKAIAVDDDDDDVVVEVAPVKKGGR KPAATKAAKPPAAPRKRGKQTVASTEVLAIGVSPEKKVRKMRSSPFNKKS SSVMSRLADNKEEESSENVAGNSSSEKSGGDVSAISRPQRANRRKMTYVL SDSESESANDSEFDDIEDDEDDE |
TOP II (Arabidopsis thaliana) is able to recognize following damages:
References:
| Title | Authors | Journal |
| Characterization of a DNA Topoisomerase II cDNA from Arabidopsis thaliana. | Xie S, Lam E | Plant Physiol Dec. 1, 1994 |
| Abundance of nuclear DNA topoisomerase II is correlated with proliferation in Arabidopsis thaliana. | Xie S, Lam E | Nucleic Acids Res Dec. 25, 1994 |
| Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones. | Kaneko T, Katoh T, Sato S, Nakamura A, Asamizu E, Tabata S | DNA Res June 1, 2000 |
Last modification of this entry: Oct. 6, 2010.
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