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RBBP8 |
Protein FULL name:
retinoblastoma-binding protein 8 isoform a [Homo sapiens].
RBBP8 (Homo sapiens) is product of expression of RBBP8 gene.
FUNCTION: May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control.
SUBUNIT: Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein.
INTERACTION: P38398:BRCA1; NbExp=5; IntAct=EBI-1263531, EBI-349905; Q6UWZ7:FAM175A; NbExp=1; IntAct=EBI-1263531, EBI-1263451;
SUBCELLULAR LOCATION: Nucleus. Note=Predominantly nuclear.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylation upon ionizing radiation results in dissociation from BRCA1.
PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable).
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; [LINK]
| NCBI GenPept GI number(s): |
4506441 |
| Species: | Homo sapiens |
Links to other databases:
| Database | ID | Link |
| Uniprot | Q99708 |
Q99708 |
| PFAM: | - |
Q99708 (Link - using uniprot id) |
| InterPro: | - |
Q99708 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MNISGSSCGSPNSADTSSDFKDLWTKLKECHDREVQGLQVKVTKLKQERI LDAQRLEEFFTKNQQLREQQKVLHETIKVLEDRLRAGLCDRCAVTEEHMR KKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQA AELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCA NEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSS FNLATVVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTR NTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSL LQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQ SSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKT EEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAI QRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSP GEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVL DDIKSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSF ENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVL LKMKKQEQKGEKSSNEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADE EEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVR KKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPEN FWEVGFPSTQTCMERGYIKEDLDPCPRPKRRQPYNAIFSPKGKEQKT |
RBBP8 (Homo sapiens) is able to recognize following damages:
RBBP8 (Homo sapiens) belongs to following protein families:
References:
Last modification of this entry: Oct. 11, 2010.
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