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Pole |
Protein FULL name:
DNA polymerase epsilon catalytic subunit [Mus musculus].
Pole (Mus musculus) is product of expression of Pole gene.
FUNCTION: Participates in DNA repair and in chromosomal DNA replication.
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBUNIT: Consists of two subunits (258 kDa and 55 kDa). Interacts with RAD17 and TOPBP1 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
DOMAIN: The DNA polymerase activity domain resides in the N- terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme.
SIMILARITY: Belongs to the DNA polymerase type-B family.
| NCBI GenPept GI number(s): |
6755124 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | Q9WVF7 |
Q9WVF7 |
| PFAM: | - |
Q9WVF7 (Link - using uniprot id) |
| InterPro: | - |
Q9WVF7 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MVLRNSGRRHPEPGADGEGSRDDGPSSSVSALKRLERSQWTDKMDLRFGF ERLKEPGERTGWLINMHPTEILDEDKRLVSAVDYYFIQDDGSRFKVALPY MPYFYIAARKGCDREVSSFLSKKFQGKIAKLENVPKEDLDLPNHLVGLKR SYIKLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTTMLSSILQGGSV ITDEDETSKKIADQLDNIVDMREYDVPYHIRLSIDLRIHVAHWYNVRFRG NAFPVEITRRDDLVERPDPVVLAFDIETTKLPLTFPDAETDQIMMISYMI DGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEVHLIQRWFEH IQETKPTIMVTYNGDFFDWPFVEARAAIHGLSMYQEIGFQKDSQGEYKAP QCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATE QPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTL CEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDAETYVGGHVEALESG VFRSDIPCRFRMNPAAFDFLLQRVEKTMRHAIEEEEKVPVEQATNFQEVC EQIKTKLTSLKDVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAIVDEAT CAACDFNKPGASCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFP EGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHVTKVEERLTTICQRE NSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDASEVKRCKNMEIL YDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELI EQIGRPLELDTDGIWCVLPNSFPENFVIKTTNAKKPKLTISYPGAMLNIM VKEGFTNHQYQELTEPSSLTYVTHSENSIFFEVDGPYLAMILPASKEEGK KLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLE EVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQK STSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQ AEPTVRKHFLRKWLKSSSLQDFDIRTILDWDYYIERLGSAIQKIITIPAA LQQVKNPVPRVKHPDWLHKKLLEKNDIYKQKKISELFVLEGKRQIVMAQA SENSLSLCTPDMEDIGLTKPHHSTVPVATKRKRVWETQKESQDIALTVPW QEVLGQPPSLGTTQEEWLVWLQFHKKKWQLQAQQRLALRKKQRLESAEDM PRLGPIREGPSTGLGSFLRKTARSIMDLPWQIIQISETRQAGLFRLWAII GNDLHCIKLSIPRVFYVNQRVAKAEDGPAYRKVNRALPRSNIVYNLYEYS VPEDMYQEHINEINTELSVPDIEGVYETQVPLLFRALVQLGCVCVVNKQL TRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHTQGHKALFG VFIPSQRRASVFVLDTVRSNQMPGLSALYSSEHSLLLDKVDPKLLPPPKH TFEVRAETNLETICRAIQRFLLAYKEERRGPTLIAVQSSWELCRLTSEIP VLEEFPLVPIRVADKISYAVLDWQRHGARRMIRHYLNLDLCLSQAFEMSR YFHIPVGNLPEDISTFGSDLFFARHLQHHNHLLWLSPTSRPDLGGKEADD NRLVMEFDDRATVEINSSGCYSTVCVELDIQNLAVNTILQSHHVNDMEGA GSMGISFDVIQQASLEDMVTGNQAASALANYDETALCSSTFRILKSMVVG WVKEITQYHNIYADNQVMHFYRWLQSPCSLLHDPALHRTLHNMMKKLFLQ LIAEFKRLGSSVVYANFNRIILCTKKRRIEDALAYVEYITNSIHSKEIFH SLTISFSRCWEFLLWMDPSNYGGIKGKVPSSIHCGQVKEQDSQAREETDE EEEDKEKDEEEEGMGESEVEDLLENNWNILQFLPQAASCQSYFLMIVSAY IVAVYQSMKEELRHSAPGSTPVKRKGASQFSQESEGATGSLPGMITFSQD YVANELTQSFFTITQKIQKKVTGSRNTTEPSEMFPILPGSHLLLNNPALE FIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCHSYVL PEVICHSCNFCRDLDLCKDSSFSQDGAILPQWLCSNCQAPYDSSAIESAL VEALQRKLMAFTLQDLVCLKCRGMKETHMPVYCSCAGDFTLTIRTEVFME QIRIFQNIAKYYSMSYLQETIEWLLQTSPVSNC |
Pole (Mus musculus) is able to recognize following damages:
Pole (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| cDNA and structural organization of the gene Pole1 for the mouse DNA polymerase epsilon catalytic subunit. | Huang D, Knuuti R, Palosaari H, Pospiech H, Syvaoja JE | Biochim Biophys Acta June 9, 1999 |
Last modification of this entry: Oct. 6, 2010.
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