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Lig3 |
Protein FULL name:
DNA ligase 3 [Mus musculus].
Lig3 (Mus musculus) is product of expression of Lig3 gene.
FUNCTION: The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase.
CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
COFACTOR: Magnesium (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: The alpha isoform is expressed in all tissues, while the beta isoform is expressed only in the testis.
DEVELOPMENTAL STAGE: During male germ cell differentiation, expression of the beta isoform begins in the later stages of meiotic prophase and ends in the round spermatid stage.
SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
SIMILARITY: Contains 1 BRCT domain.
SIMILARITY: Contains 1 PARP-type zinc finger.
| NCBI GenPept GI number(s): |
71061470 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | P97386 |
P97386 |
| PFAM: | - |
P97386 (Link - using uniprot id) |
| InterPro: | - |
P97386 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MTLAFKILFPRNLCALGRKELCLFPEQNRWAAISQFSQWSETNLLGGCCL LQRRKPVLALQRGHLRPRATHLTFWPGSHVGLCTGPCAMAEQRFCVDYAK RGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLER ARATTKKIEDLTELEGWEELEDNEKEQISQHIADLSSKAAATPKKKAAVQ AKLTTTGQVTSPVKGASFITSTNPRKFSGFSAAKPNNSEQAPSSPAPGTS LSASKCDPKHKDCLLREFRKLCAMVAENPSYNTKTQIIHDFLQKGSTGDG FHGDVYLTVKLLLPGVIKSVYNLNDKQIVKLFSRIFNCNPDDMARDLEQG DVSETIRIFFEQSKSFPPAAKSLLTIQEVDAFLLHLSKLTKEDEQQQALQ DIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQ DVVERVLHNEQEVEKDPGRRRALRVQASLMTPVQPMLAEACKSIEYAMKK CPNGMFSEIKYDGERVQVHKKGDHFSYFSRSLKPVLPHKVAHFKDYIPKA FPGGQSMILDSEVLLIDNNTGKPLPFGTLGVHKKAAFQDANVCLFVFDCI YFNDVSLMDRPLCERRKFLHDNMVEIRNRIMFSEMKQVTKASDLADMINR VIREGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAF YGQGSKGGMMSIFLMGCYDPDSQKWCTVTKCAGGHDDATLARLQKELVMV KISKDPSKIPSWLKINKIYYPDFIVPDPKKAAVWEITGAEFSRSEAHTAD GISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKDKADFAVVAGDEASP TTGGSSGENEGTAGSAGPCKGPPSKSSASAKTTEQKLNSPSSRGGIKPIP KHSPMKPGEKLAVKSSPVKVGMKRKATDETPCLKKVLLDVFTGVRLYLPP STPDFKRLKRYFVAFDGDLVQEFDMGSATHVLGNREKNTDAQLVSSEWIW ACIRKRRLIAPC |
Lig3 (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombination. | Mackey ZB, Ramos W, Levin DS, Walter CA, McCarrey JR, Tomkinson AE | Mol Cell Biol Jan. 1, 1997 |
| Large-scale phosphorylation analysis of mouse liver. | Villen J, Beausoleil SA, Gerber SA, Gygi SP | Proc Natl Acad Sci U S A Feb. 1, 2007 |
Last modification of this entry: Oct. 6, 2010.
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