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Msh3 |
Protein FULL name:
DNA mismatch repair protein Msh3 [Mus musculus].
Msh3 (Mus musculus) is product of expression of Msh3 gene.
FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis (By similarity).
SUBUNIT: Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1 (By similarity).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).
SIMILARITY: Belongs to the DNA mismatch repair mutS family. MSH3 subfamily.
| NCBI GenPept GI number(s): |
68299763 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | P13705 |
P13705 |
| PFAM: | - |
P13705 (Link - using uniprot id) |
| InterPro: | - |
P13705 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MPRGKSASGGSTAAGPGPGRQTVLSRFFRSAGSLRSSASSTEPAEKVTEG DSRKRSLGNGGPTKKKARKVPEKEEENISVAAHHPEAKKCLRPRIVLKSL EKLKEFCCDSALPQNRVQTEALRERLEVLPRCTDFEDITLQRAKNAVLSE DSKSQANQKDSQFGPCPEVFQKTSDCKPFNKRSKSVYTPLELQYLDMKQQ HKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFV HVRRLVAKGYKVGVVKQTETAALKAIGDNKSSVFSRKLTALYTKSTLIGE DVNPLIRLDDSVNIDEVMTDTSTNYLLCIYEEKENIKDKKKGNLSVGIVG VQPATGEVVFDCFQDSASRLELETRISSLQPVELLLPSDLSVPTEMLIQR ATNVSVRDDRIRVERMNNTYFEYSHAFQTVTEFYAREIVDSQGSQSLSGV INLEKPVICALAAVIRYLKEFNLEKMLSKPESFKQLSSGMEFMRINGTTL RNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKNWVTQPLLKLREINA RLDAVSDVLHSESSVFEQIENLLRKLPDVERGLCSIYHKKCSTQEFFLIV KSLCQLKSELQALMPAVNSHVQSDLLRALIVEAPELLSPVEHYLKVLNGP AAKVGDKTELFKDLSDFPLIKKRKNEIQEVIHSIQMRLQEFRKILKLPSL QYVTVSGQEFMIEIKNSAVSCIPADWVKVGSTKAVSRFHPPFIVESYRRL NQLREQLVLDCNAEWLGFLENFGEHYHTLCKAVDHLATVDCIFSLAKVAK QGNYCRPTLQEEKKIIIKNGRHPMIDVLLGEQDQFVPNSTSLSQDSERVM IITGPNMGGKSSYIKQVALVTIMAQIGSYVPAEEATIGIVDGIFTRMGAA DNIYKGRSTFMEELTDTAEIIRRASPQSLVILDELGRGTSTHDGIAIAYA TLEYFIRDVKSLTLFVTHYPPVCELEKCYPEQVGNYHMGFLVNEDESKQD SGDMEQMPDSVTFLYQITRGIAARSYGLNVAKLADVPREVLQKAAHKSKE LEGLVSLRRKRLECFTDLWTTHSVKDLHTWADKLEMEEIQTSLPH |
Msh3 (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene. | Linton JP, Yen JY, Selby E, Chen Z, Chinsky JM, Liu K, Kellems RE, Crouse GF | Mol Cell Biol July 1, 1989 |
| Characterization of the mouse Rep-3 gene: sequence similarities to bacterial and yeast mismatch-repair proteins. | Liu K, Niu L, Linton JP, Crouse GF | Gene Sept. 1, 1994 |
Last modification of this entry: Oct. 6, 2010.
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