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Ercc4 |
Protein FULL name:
excision repair cross-complementing rodent repair deficiency, complementation group 4 [Mus musculus].
Ercc4 (Mus musculus) is product of expression of Ercc4 gene.
FUNCTION: Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link (By similarity).
COFACTOR: Magnesium (By similarity).
SUBUNIT: Heterodimer composed of ERCC1 and XPF/ERCC4. Interacts with EME1. Interacts with BTBD12/SLX4; this interaction is direct and links the ERCC1-XPF/ERCC1 complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the XPF family.
SIMILARITY: Contains 1 ERCC4 domain.
SEQUENCE CAUTION: Sequence=AAH26792.1; Type=Erroneous initiation;
| NCBI GenPept GI number(s): |
7657064 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | Q9QZD4 |
Q9QZD4 |
| PFAM: | - |
Q9QZD4 (Link - using uniprot id) |
| InterPro: | - |
Q9QZD4 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MEPGLSGERRSMAPLLEYERQQVLELLDSNGLVVCARGLGTDRLLYHFLR LHCHPACLVLVLNTQPAEEEYFINQLKIEGVEHLPRRVTNEIASNSRYEV YTQGGIIFATSRILVVDFLTGRIPSDLITGILVYRAHRIIESCQEAFILR LFRQKNKRGFIKAFTDNAVAFDTGFCHVERVMRNLFVRKLYLWPRFHVAV NSFLEQHKPEVVEIHVSMTPAMLAIQTAILDILNACLKELKCHNPSLEVE DLSLENALGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQ YDCVTFLNLLESLRATEKVFGQNSGWLFLDASTSMFVNARARVYRVPDVK LNKKAKTSEKTSSPEVQETKKELVLESNPKWEALTDVLKEIEAENKESEA LGGPGRVLICASDDRTCCQLRDYLSAGAETFLLRLYRKTFEKDGKAEEVW VNVRKGDGPKRTTKSDKRPKAAPNKERASAKRGAPLKRKKQELTLTQVLG SAEEPPEDKALEEDLCRQTSSSPEGCGVEIKRESFDLNVSSDAAYGILKE PLTIIHPLLGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRP GKPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEEREGR DETNLDLARGSAALDAPTDTRKAGGQEQNGTQSSIVVDMREFRSELPSLI HRRGIDIEPVTLEVGDYILTPELCVERKSVSDLIGSLHSGRLYSQCLAMS RYYRRPVLLIEFDPSKPFSLAPRGAFFQEMSSSDVSSKLTLLTLHFPRLR LLWCPSPHATAELFEELKQNKPQPDAATAMAITADSETLPESDRYNPGPQ DFVLKMPGVNAKNCRSLMNQVKNIAELATLSLERLTTILGHSGNAKQLHD FLHTAYADLVSKGRVRK |
Ercc4 (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| Characterization of the mouse Xpf DNA repair gene and differential expression during spermatogenesis. | Shannon M, Lamerdin JE, Richardson L, McCutchen-Maloney SL, Hwang MH, Handel MA, Stubbs L, Thelen MP | Genomics Dec. 15, 1999 |
| The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J | Genome Res Oct. 1, 2004 |
Last modification of this entry: Oct. 6, 2010.
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