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Ercc5 |
Protein FULL name:
DNA repair protein complementing XP-G cells homolog [Mus musculus].
Ercc5 (Mus musculus) is product of expression of Ercc5 gene.
FUNCTION: Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too (By similarity).
COFACTOR: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding (By similarity).
SUBUNIT: Interacts with PCNA (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
| NCBI GenPept GI number(s): |
170172544 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | P35689 |
P35689 |
| PFAM: | - |
P35689 (Link - using uniprot id) |
| InterPro: | - |
P35689 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MGVQGLWKLLECSGHRVSPEALEGKVLAVDISIWLNQALKGVRDSHGNVI ENAHLLTLFHRLCKLLFFRIRPIFVFDGDAPLLKKQTLAKRRQRKDSASI DSRKTTEKLLKTFLKRQALKTAFRSSRHEAPPSLTQVQRQDDIYVLPPLP EEEKHSSEEEDEKQWQARMDQKQALQEEFFHNPQAIDIESEDFSSLPPEV KHEILTDMKEFTKRRRTLFEAMPEESNDFSQYQLKGLLKKNYLNQHIENV QKEMNQQHSGQIQRQYQDEGGFLKEVESRRVVSEDTSHYILIKGIQGKKV MDVDSESLPSSSNVHSVSSNLKSSPHEKVKPEREPEAAPPSPRTLLAIQA AMLGSSSEDEPESREGRQSKERNSGATADAGSISPRTCAAIQKALDDDND EKVSGSSDDLAEKMLLGSGLEQEEHADETAERGGGVPFDTAPLTPSVTEV KECVTSGSSANGQTDSAHSFTTASHRCDTPKETVSLARAVKEASQISSEC EVEGRPAALSPAFIGTPSSHVSGVLSEREPTLAPPTTRTHSDQGIDIHPE DPELQNGLYPLETKCNSSRLSSDDETEGGQNPAPKACSTVHVPAEAMSNL ENALPSNAEERGDFQETIQLREVPEAAARELISAPKPMGPMEMESEESES DGSFIEVQSVVSNSELQTESSEASTHLSEKDAEEPRETLEEGTSRDTECL LQDSSDIEAMEGHREADIDAEDMPNEWQDINLEELDALESNLLAEQNSLK AQKQQQDRIAASVTGQMFLESQELLRLFGVPYIQAPMEAEAQCAMLDLTD QTSGTITDDSDIWLFGARHVYKNFFNKNKFVEYYQYVDFYSQLGLDRNKL INLAYLLGSDYTEGIPTVGCVTAMEILNEFPGRGLDPLLKFSEWWHEAQN NKKVAENPYDTKVKKKLRKLQLTPGFPNPAVADAYLRPVVDDSRGSFLWG KPDVDKIREFCQRYFGWNRMKTDESLYPVLKHLNAHQTQLRIDSFFRLAQ QEKQDAKLIKSHRLNRAVTCILRKEREEKAPELTKVTEALDDAKGKTQKR ELPYKKETSVPKRRRPSGNGGFLGDPYCSESPQESSCEDGEGSSVMSARQ RSAAESSKISCSDVPDLVRDPPHGRQGCVSTSSSSEDDEDKAKTVLVTAR PVFGKKKLKLKSMKRRKKKT |
Ercc5 (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| An ERCC5 gene with homology to yeast RAD2 is involved in group G xeroderma pigmentosum. | Shiomi T, Harada Y, Saito T, Shiomi N, Okuno Y, Yamaizumi M | Mutat Res March 1, 1994 |
| Complementary DNA sequence and chromosomal localization of xpg, the mouse counterpart of human repair gene XPG/ERCC5. | Harada YN, Matsuda Y, Shiomi N, Shiomi T | Genomics July 1, 1995 |
| Molecular cloning and structural analysis of the functional mouse genomic XPG gene. | Ludwig DL, Mudgett JS, Park MS, Perez-Castro AV, MacInnes MA | Mamm Genome Sept. 1, 1996 |
| Large-scale phosphorylation analysis of mouse liver. | Villen J, Beausoleil SA, Gerber SA, Gygi SP | Proc Natl Acad Sci U S A Feb. 1, 2007 |
Last modification of this entry: Oct. 6, 2010.
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