Welcome! Click here to login or here to register.
 |
|||||||||||||||||||
|
|||||||||||||||||||
 |
|||||||||||||||||||
Recql |
Protein FULL name:
ATP-dependent DNA helicase Q1 [Mus musculus].
Recql (Mus musculus) is product of expression of Recql gene.
FUNCTION: Isoform alpha is a DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Isoform beta may have important roles in the meiotic process. Both isoforms exhibit a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
SUBUNIT: Interacts with EXO1 and MLH1 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Isoform alpha is expressed in all tissues examined. Isoform beta is only expressed in spermatocytes, expression increases at pachytene (17 days old) and decreases after completion of meiosis II (7 weeks old).
SIMILARITY: Belongs to the helicase family. RecQ subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.
| NCBI GenPept GI number(s): |
110625690 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | Q9Z129 |
Q9Z129 |
| PFAM: | - |
Q9Z129 (Link - using uniprot id) |
| InterPro: | - |
Q9Z129 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MASVSALTEELESVASELHAIDIQIQELTERRQELLQRKSVLTGKIKQYL EDSSAEASSDLDTSPAAWNKEDFPWFGKVKDVLQNVFKLQKFRPLQLETI NVTMARKDIFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMV LKQLGISATMLNASSSKEHVKWVHAEMVNKNSQLKLIYVTPEKIAKSKMF MSRLEKAYEAGRLTGAAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASL MGLTATATNHVLKDVQKILCVGKCLTFTASFNRPNLFYEVRQKPSSAEDF TEDIVKLINGRYKGQSGIIYCFSQKDSEQITISLQKLGIHAGTYHANMEP EDKTKVHTQWSANELQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQ ESGRAGRDDSRADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNV SKCRRVLIAQHFDEVWNADACNKMCDNCCKDVSFEKKNVTQHCRDLIKIL KQAEGLNEKLTPLKLIDAWMGKGAAKLRVAGVVAPALPREDLERIVAHAL LQQYLKEDYSFTAYATISYLKVGPRACLLSNEAHAVTMQVKKSAQSSVRG ALSEARQVEQVDSKGEEQSSGNSQKSKSRLQPSGSKNAGAKKRKLDDA |
Recql (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| Cloning of two isoforms of mouse DNA helicase Q1/RecQL cDNA; alpha form is expressed ubiquitously and beta form specifically in the testis. | Wang WS, Seki M, Yamaoka T, Seki T, Tada S, Katada T, Fujimoto H, Enomoto T | Biochim Biophys Acta Nov. 26, 1998 |
Last modification of this entry: Oct. 6, 2010.
Add your own comment!
There is no comment yet.
|
|
|
|