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Fanca |
Protein FULL name:
Fanconi anemia, complementation group A [Mus musculus].
Fanca (Mus musculus) is product of expression of Fanca gene.
FUNCTION: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).
SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=The major form is nuclear. The minor form is cytoplasmic.
TISSUE SPECIFICITY: Mainly expressed in testis and lymphoid tissues like thymus, lymph nodes, and spleen, and at lower levels in kidney and ovary.
PTM: Phosphorylated primarily on serine residues. Phosphorylation is required for the formation of the nuclear complex (By similarity).
| NCBI GenPept GI number(s): |
8393352 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | Q9JL70 |
Q9JL70 |
| PFAM: | - |
Q9JL70 (Link - using uniprot id) |
| InterPro: | - |
Q9JL70 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MPGSPARGAAMGGGPRGLRKTWTELLAGRVKKQKYDPEREQKLKDSALKL LRYHQNMHDLLLEVEEPQCKRLRLSELIDRDSADASSDRSASFIRSAFRD QASRLGVPVGVLSAKVFARSVQQVCVEPSHPVLLSPEQSKKLSSLLVIAR HLLAQNMFSRLTFCQELWKAQNSLLLEAMWRLHTHSVVSLQELLQSHPDS EAMAMWLFRNLRSLCEQIGASCPSPDTTEAMLSGLVQLLISRGFQGSSDP RRLVEPERLPQVATDVLQRMLAFSLDTLEADPQTTLDCQAVSGWIPIYSG HTCCGVVTEDSLKSFFSHTLTQTLTHKPVLKVSDAIQMQKEWSFAKTHHL LTDLHCRVLATLGPEESVGRLQEVLEMQEVNWQHVLSCVSTLVVCFPEAQ QLVKGWVASLMARAFESYHLDSMGTAFLIVRQATLEGPYVFPSYADWFKE SFGSSHGYHSCSKKTLVFLFKFLSDLVPWEAPRYMQVHIFHPPLVPSKYH SLLTDYISLAKTRLADLKVSLENVGLYEDLSSPGDIAERESQAVQDVKKA IMVFEQTGKIPMPVLEASIFRRPYYVSHFLPTLLAPRVLPEVPDPRVAFI ETLKRADKIPSSIYDAYRKACASAEKQQPENATSAQRTEADCAKEPLGLL TAALEELRALMTDPTQYSVISAQVAVVSEKLNAVLGHRNDGGSLQRAKIQ LSVLPSTLQKQDQAVVDLLLTAFCQNLMAASSFVPPERQSPWAVLFVRTL CGHVLLPAVLTRLRQLLRHQGQSLSTSHVLGLAALAVHLGECRSMLPEVD PDVLAPSAGSLCVPDFLNSLLTCRTRDSLLFCMNFCTAAVSYCLCKFSAL RNCLSPGLIKKFQFVVLRLFPEARAPCAPEHAACVPWRPLYLPSADWQRA ALSLWRRDSFQELLKDKEFYLTYRDWVQLELEIQPEADVLSDMERHDFHQ WAIYERYLPAPTALGGCGGDLEEACTVLVSEIMDFHQSSRSYNHSEDSDL VLGGRTGNKDILSRLQEIALDLELDQGSAVPHGCSTPQSHFLFRVFRRRL QALARPDSMATSLRRQQELLTCKRLLLCLPPSVLVGGPQAGQPISPNCGE FFSLVNSELRNFCCHGSVLTSDITIHFFRGLLRVCLRSQDPALVANQTLT ECQTKCPVILTSALLWWSSLEPVLCGRWMRCYQSPLPRELRRLQEAREFA SNFASASASPAPSPAWIAAAALHFAWRGVRKEDVTAHLQRLDCQREELLI ALFFFSLMGLLSSYLTQRDTAEHLKAVDICAEVLTCLERRKVSWLVLFQL TEKDAKLGHLLHLAPDQHTRLLPLAFYSLLSCFSEGAAVREAAFLHVAVD MYLKLLQLFVDGETRLQGHSESQGSPVQLITKARVFLLQLIPQCPKQCFS NMTELLAGRGDCDPEVSNALRQRQQADPSFDLYQEPQLF |
Fanca (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| Cloning and characterization of murine fanconi anemia group A gene: Fanca protein is expressed in lymphoid tissues, testis, and ovary. | van de Vrugt HJ, Cheng NC, de Vries Y, Rooimans MA, de Groot J, Scheper RJ, Zhi Y, Hoatlin ME, Joenje H, Arwert F | Mamm Genome April 1, 2000 |
| Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. | Wong JC, Alon N, Norga K, Kruyt FA, Youssoufian H, Buchwald M | Genomics Aug. 1, 2000 |
Last modification of this entry: Oct. 6, 2010.
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