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Brca2 |
Protein FULL name:
breast cancer type 2 susceptibility protein homolog [Mus musculus].
Brca2 (Mus musculus) is product of expression of Brca2 gene.
FUNCTION: Involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation.
SUBUNIT: Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoints functions. Interacts with WDR16 (By similarity).
INTERACTION: P60896:SHFM1 (xeno); NbExp=1; IntAct=EBI-1034100, EBI-79819;
TISSUE SPECIFICITY: Widely expressed. Highest expression in cerebellum, testis, ileum, appendix, epididymis, ovary and mammary gland. No expression in lung.
DEVELOPMENTAL STAGE: In the mammary gland, expression increases dramatically during pregnancy.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).
SIMILARITY: Contains 7 BRCA2 repeats.
| NCBI GenPept GI number(s): |
124487409 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | P97929 |
P97929 |
| PFAM: | - |
P97929 (Link - using uniprot id) |
| InterPro: | - |
P97929 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MPVEYKRRPTFWEIFKARCSTADLGPISLNWFEELSSEAPPYNSEPPEES EYKPHGYEPQLFKTPQRNPPYHQFASTPIMFKERSQTLPLDQSPFRELGK VVASSKHKTHSKKKTKVDPVVDVASPPLKSCLSESPLTLRCTQAVLQREK PVVSGSLFYTPKLKEGQTPKPISESLGVEVDPDMSWTSSLATPPTLSSTV LIARDEEARSSVTPADSPATLKSCFSNHNESPQKNDRSVPSVIDSENKNQ QEAFSQGLGKMLGDSSGKRNSFKDCLRKPIPNILEDGETAVDTSEEDSFS LCFPKRRTRNLQKMRMGKTRKKIFSETRTDELSEEARRQTDDKNSFVFEM ELRESDPLDPGVTSQKPFYSQNEEICNEAVQCSDSRWSQSNLSGLNETQT GKITLPHISSHSQNISEDFIDMKKEGTGSITSEKSLPHISSLPEPEKMFS EETVVDKEHEGQHFESLEDSIAGKQMVSRTSQAACLSPSIRKSIFKMREP LDETLGTVFSDSMTNSTFTEEHEASACGLGILTACSQREDSICPSSVDTG SWPTTLTDTSATVKNAGLISTLKNKKRKFIYSVSDDASLQGKKLQTHRQL ELTNLSAQLEASAFEVPLTFTNVNSGIPDSSDKKRCLPNDPEEPSLTNSF GTATSKEISYIHALISQDLNDKEAIVIEEKPQPYTAREADFLLCLPERTC ENDQKSPKVSNGKEKVLVSACLPSAVQLSSISFESQENPLGDHNGTSTLK LTPSSKLPLSKADMVSREKMCKMPEKLQCESCKVNIELSKNILEVNEICI LSENSKTPGLLPPGENIIEVASSMKSQFNQNAKIVIQKDQKGSPFISEVA VNMNSEELFPDSGNNFAFQVTNKCNKPDLGSSVELQEEDLSHTQGPSLKN SPMAVDEDVDDAHAAQVLITKDSDSLAVVHDYTEKSRNNIEQHQKGTEDK DFKSNSSLNMKSDGNSDCSDKWSEFLDPVLNHNFGGSFRTASNKEIKLSE HNVKKSKMFFKDIEEQYPTRLACIDIVNTLPLANQKKLSEPHIFDLKSVT TVSTQSHNQSSVSHEDTDTAPQMLSSKQDFHSNNLTTSQKAEITELSTIL EESGSQFEFTQFRKPSHIAQNTSEVPGNQMVVLSTASKEWKDTDLHLPVD PSVGQTDHSKQFEGSAGVKQSFPHLLEDTCNKNTSCFLPNINEMEFGGFC SALGTKLSVSNEALRKAMKLFSDIENSEEPSAKVGPRGFSSSAHHDSVAS VFKIKKQNTEKSFDEKSSKCQVTLQNNIEMTTCIFVGRNPEKYIKNTKHE DSYTSSQRNNLENSDGSMSSTSGPVYIHKGDSDLPADQGSKCPESCTQYA REENTQIKENISDLTCLEIMKAEETCMKSSDKKQLPSDKMEQNIKEFNIS FQTASGKNTRVSKESLNKSVNIFNRETDELTVISDSLNSKILHGINKDKM HTSCHKKAISIKKVFEDHFPIVTVSQLPAQQHPEYEIESTKEPTLLSFHT ASGKKVKIMQESLDKVKNLFDETQYVRKTASFSQGSKPLKDSKKELTLAY EKIEVTASKCEEMQNFVSKETEMLPQQNYHMYRQTENLKTSNGTSSKVQE NIENNVEKNPRICCICQSSYPVTEDSALAYYTEDSRKTCVRESSLSKGRK WLREQGDKLGTRNTIKIECVKEHTEDFAGNASYEHSLVIIRTEIDTNHVS ENQVSTLLSDPNVCHSYLSQSSFCHCDDMHNDSGYFLKNKIDSDVPPDMK NAEGNTISPRVSATKERNLHPQTINEYCVQKLETNTSPHANKDVAIDPSL LDSRNCKVGSLVFITAHSQETERTKEIVTDNCYKIVEQNRQSKPDTCQTS CHKVLDDSKDFICPSSSGDVCINSRKDSFCPHNEQILQHNQSMSGLKKAA TPPVGLETWDTSKSIREPPQAAHPSRTYGIFSTASGKAIQVSDASLEKAR QVFSEMDGDAKQLSSMVSLEGNEKPHHSVKRENSVVHSTQGVLSLPKPLP GNVNSSVFSGFSTAGGKLVTVSESALHKVKGMLEEFDLIRTEHTLQHSPI PEDVSKILPQPCAEIRTPEYPVNSKLQKTYNDKSSLPSNYKESGSSGNTQ SIEVSLQLSQMERNQDTQLVLGTKVSHSKANLLGKEQTLPQNIKVKTDEM KTFSDVPVKTNVGEYYSKESENYFETEAVESAKAFMEDDELTDSEQTHAK CSLFTCPQNETLFNSRTRKRGGVTVDAVGQPPIKRSLLNEFDRIIESKGK SLTPSKSTPDGTVKDRSLFTHHMSLEPVTCGPFCSSKERQGAQRPHLTSP AQELLSKGHPWRHSALEKSPSSPIVSILPAHDVSATRTERTRHSGKSTKV FVPPFKMKSQFHGDEHFNSKNVNLEGKNQKSTDGDREDGNDSHVRQFNKD LMSSLQSARDLQDMRIKNKERRHLRLQPGSLYLTKSSTLPRISLQAAVGD RAPSACSPKQLYIYGVSKECINVNSKNAEYFQFDIQDHFGKEDLCAGKGF QLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISSIWVANHYRWIVW KLAAMEFAFPKEFANRCLNPERVLLQLKYRYDVEIDNSRRSALKKILERD DTAAKTLVLCISDIISPSTKVSETSGGKTSGEDANKVDTIELTDGWYAVR AQLDPPLMALVKSGKLTVGQKIITQGAELVGSPDACAPLEAPDSLRLKIS ANSTRPARWHSRLGFFRDPRPFPLPLSSLFSDGGNVGCVDIIVQRVYPLQ WVEKTVSGLYIFRSEREEEKEALRFAEAQQKKLEALFTKVHTEFKDHEED TTQRCVLSRTLTRQQVHALQDGAELYAAVQYASDPDHLEACFSEEQLRAL NNYRQMLNDKKQARIQSEFRKALESAEKEEGLSRDVTTVWKLRVTSYKKK EKSALLSIWRPSSDLSSLLTEGKRYRIYHLAVSKSKSKFERPSIQLTATK RTQYQQLPVSSETLLQVYQPRESLHFSRLSDPAFQPPCSEVDVVGVVVSV VKPIGLAPLVYLSDECLNLLVVKFGIDLNEDIKPRVLIAASNLQCQPEST SGVPTLFAGHFSIFSASPKEAYFQEKVNNLKHAIENIDTFYKEAEKKLIH VLEGDSPKWSTPNKDPTREPHAASTCCASDLLGSGGQFLRISPTGQQSYQ SPLSHCTLKGKSMPLAHSAQMAAKSWSGENEIDDPKTCRKRRALDFLSRL PLPSPVSPICTFVSPAAQKAFQPPRSCGTKYATPIKKEPSSPRRRTPFQK TSGVSLPDCDSVADEELALLSTQALTPDSVGGNEQAFPGDSTRNPQPAQR PDQQVGPRSRKESLRDCRGDSSEKLAVES |
Brca2 (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. | Rajan JV, Wang M, Marquis ST, Chodosh LA | Proc Natl Acad Sci U S A Nov. 12, 1996 |
| Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene. | Connor F, Smith A, Wooster R, Stratton M, Dixon A, Campbell E, Tait TM, Freeman T, Ashworth A | Hum Mol Genet Jan. 1, 1997 |
| Murine Brca2: sequence, map position, and expression pattern. | Sharan SK, Bradley A | Genomics March 1, 1997 |
| Genetic mapping of the Brca2 breast cancer susceptibility gene on mouse chromosome 5. | McAllister KA, Ramachandran S, Haugen-Strano A, Fiedorek FT Jr, Wiseman RW | Mamm Genome July 1, 1997 |
| Characterization of the rat and mouse homologues of the BRCA2 breast cancer susceptibility gene. | McAllister KA, Haugen-Strano A, Hagevik S, Brownlee HA, Collins NK, Futreal PA, Bennett LM, Wiseman RW | Cancer Res Aug. 1, 1997 |
Last modification of this entry: Oct. 6, 2010.
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