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Pold1 |
Protein FULL name:
DNA-directed DNA polymerase delta 1 [Mus musculus].
Pold1 (Mus musculus) is product of expression of Pold1 gene.
FUNCTION: Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBUNIT: Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. The 125 kDa subunit contains the polymerase active site and most likely the active site for the 3'-5' exonuclease activity. Interacts with WRNIP1. Interacts with POLD4 and PCNA (By similarity).
SUBCELLULAR LOCATION: Nucleus.
MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
SIMILARITY: Belongs to the DNA polymerase type-B family.
| NCBI GenPept GI number(s): |
31981551 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | P52431 |
P52431 |
| PFAM: | - |
P52431 (Link - using uniprot id) |
| InterPro: | - |
P52431 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MDCKRRQGPGPGVPPKRARGHLWDEDEPSPSQFEANLALLEEIEAENRLQ EAEEELQLPPEGTVGGQFSTADIDPRWRRPTLRALDPSTEPLIFQQLEID HYVGSAPPLPEGPPPSRNSVPILRAFGVTDEGFSVCCHIQGFAPYFYTPA PPGFGAEHLSELQQELNAAISRDQRGGKELSGPAVLAIELCSRESMFGYH GHGPSPFLRITLALPRLMAPARRLLEQGVRVPGLGTPSFAPYEANVDFEI RFMVDADIVGCNWLELPAGKYVRRAEKKATLCQLEVDVLWSDVISHPPEG QWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLR LALTLRPCAPILGAKVQSYEREEDLLQAWADFILAMDPDVITGYNIQNFD LPYLISRAQALKVDRFPFLGRVTGLRSNIRDSSFQSRQVGRRDSKVISMV GRVQMDMLQVLLREHKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNE QTRRRLAVYCLKDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLTRGQQ VKVVSQLLRQAMRQGLLMPVVKTEGGEDYTGATVIEPLKGYYDVPIATLD FSSLYPSIMMAHNLCYTTLLRPGAAQKLGLKPDEFIKTPTGDEFVKSSVR KGLLPQILENLLSARKRAKAELAQETDPLRRQVLDGRQLALKVSANSVYG FTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYDANAKVV YGDTDSVMCRFGVSSVAEAMSLGREAANWVSSHFPSPIRLEFEKVYFPYL LISKKRYAGLLFSSRSDAHDKMDCKGLEAVRRDNCPLVANLVTSSLRRIL VDRDPDGAVAHAKDVISDLLCNRIDISQLVITKELTRAAADYAGKQAHVE LAERMRKRDPGSAPSLGDRVPYVIIGAAKGVAAYMKSEDPLFVLEHSLPI DTQYYLEQQLAKPLLRIFEPILGEGRAESVLLRGDHTRCKTVLTSKVGGL LAFTKRRNCCIGCRSVIDHQGAVCKFCQPRESELYQKEVSHLNALEERFS RLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQERLLQRFGPP GPEAW |
Pold1 (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| Cloning of a mouse cDNA encoding DNA polymerase delta: refinement of the homology boxes. | Cullmann G, Hindges R, Berchtold MW, Hubscher U | Gene Dec. 8, 1993 |
| Mouse DNA polymerase delta gene (Pold1) maps to chromosome 7. | Goldsby RE, Singh M, Preston BD | Mamm Genome Feb. 1, 1998 |
Last modification of this entry: Oct. 6, 2010.
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